線(xiàn)性化聚乙烯亞胺 Max PEI MAX 40000 生化試劑
簡(jiǎn)要描述:
線(xiàn)性化聚乙烯亞胺 Max(MW 40,000)PEI MAX 40000:是熱賣(mài)產(chǎn)品線(xiàn)性化聚乙烯亞胺PEI25,000的升級產(chǎn)品,不同之處在于1)*水解(去乙?;?;
產(chǎn)品時(shí)間:2023-02-15
Polyethylenimine HCl MAX, Linear, Mw 40,000
線(xiàn)性化聚乙烯亞胺鹽酸鹽 MAX(PEI 40,000)
基本描述:
Polyethylenimine HCl MAX, Linear, Mw 40,000(PEI 40,000)是熱賣(mài)產(chǎn)品線(xiàn)性化聚乙烯亞胺PEI25,000的升級產(chǎn)品,不同之處在于1)*水解(去乙?;?;2)PEI25,000的鹽酸鹽形式,具更高的水溶特性;3)含更長(cháng)連續性乙烯亞胺(ethyleneimine)片段,其質(zhì)子化氮水平比PEI25,000提高11%以上。本品經(jīng)堿中和后,可轉化為線(xiàn)性化自由胺(PEI),此時(shí)分子量正相當于25,000。
Thomas M,et al(2005)研究數據表明,去乙?;?/span>PEI 40,000(Polyethylenimine MAX 40,000)體外質(zhì)粒DNA轉染效率提高21倍,小鼠體內靶向效率達到10,000倍,隨之肺部特異療效顯示增強1500倍。
化學(xué)性質(zhì):
CAS NO. | 9002-98-6, 26913-06-4 |
Molecular Weight | 40,000(~22,000 free base) |
Solubility | Soluble In: Cold and room temperature water Insoluble In: Common organic solvents (ethanol, acetone, tetrahydrofuran) |
Appearance | White to off-white free flowing solid |
訂購信息:【*,現貨供應】
品牌 | 貨號 | 名稱(chēng) | 規格 | *(元) |
Polysciences | 24765-2 | 線(xiàn)性聚乙烯亞胺鹽酸鹽Max,(MW 40,000) (Equivalent to Mw 25,000 in Free Base Form) | 2g | 咨詢(xún) |
另,提供基本型PEI 25,000。 | ||||
Polysciences | 23966-2 | 線(xiàn)性聚乙烯亞胺(MW 25,000) | 2g | 咨詢(xún) |
應用文獻【基因轉染用途】 :
Mann JF, McKay PF, Arokiasamy S, Pa RK, Klein K, Shattock RJ. (2013). Pulmonary delivery of DNA vaccine constructs using deacylated PEI elicits immune responses and protects against viral challenge infection. J Control Release. 170(3):452-9.
Thomas M, Lu JJ, Ge Q, Zhang C, Chen J, Klibanov AM. (2005). Full deacylation of polyethylenimine dramatically boosts its gene delivery efficiency and specificity to mouse lung. Proc Natl Acad Sci U S A. 102(16):5679-84.
——Written/Edited by V. Shallan【版權歸MKBio懋康所有】
線(xiàn)性化聚乙烯亞胺 Max(MW 40,000)PEI MAX 40000
線(xiàn)性化聚乙烯亞胺 Max(MW 40,000)PEI MAX 40000